In present study, a non-isothermal comprehensive mathematical model is developed for performance analysis of a spouted bed reactor in which CO2 is removed by using a semi-dry chemical absorption process. For this aim, based on the hydrodynamic model of streamtube and equations of mass and energy balances for a reactive absorption process, the governing equations for gas and solid phases in three different regions of the bed are derived and solved numerically. The effects of variation of different operating parameters and process conditions are investigated and corresponding maximum, minimum and average values of errors are obtained by comparison of the model results with existing experimental ones. Results show that the superficial gas velocity and the approach to saturation temperature have considerable effects on CO2 removal efficiency, while Ca/C molar ratio, inlet concentration of CO2 and static bed height of reactor do not influence performance of the reactor significantly. (C) 2011 Elsevier B.V. All rights reserved.