The effect of mass diffusion of chemical species with first-order reaction on peristaltic motion of an incompressible Jeffrey fluid has been investigated. The fluid flows through vertical porous media in the gap between concentric tubes with heat and mass transfer. The inner tube is uniform, while the outer one is a non-uniform tube has a sinusoidal wave traveling down its wall. A perturbation solution, under long-wavelength assumption, is obtained which satisfies the momentum, energy, and concentration equations for the case of small porosity parameter. Numerical results for the behaviors of pressure rise and frictional force per wavelength as well as for the skin friction, Nusselt number, and Sherwood number with other physical parameters are obtained. Several graphs for these results of physical interest are displayed and discussed in detail.