The problem of steady, laminar, mixed convection boundary-layer flow over an isothermal vertical wedge embedded in a porous medium saturated with a nanofluid is studied, in the presence of thermal radiation. The model used for the nanofluid incorporates the effects of Brownian motion and thermophoresis with Rosseland diffusion approximation. The wedge surface is maintained at a constant temperature and a constant nanoparticle volume fraction. The resulting governing equations are non-dimensionalized and transformed into a non-similar form and then solved by Keller box method. A comparison is made with the available results in the literature, and our results are in very good agreement with the known results. A parametric study of the physical parameters is made, and a representative set of numerical results for the velocity, temperature, and volume fraction, the local Nusselt and Sherwood numbers are presented graphically. The salient features of the results are analyzed and discussed.