A transient, two-dimensional theoretical analysis of combined hear and mass transfer and adsorption/desorption dynamics is presented to investigate the effects of the local non-linear interactions between heat and mass transfer and adsorption/desorption as the surface phenomena. A honeycomb adsorption column is used as a model system. The simplified statistical mechanics (SLD) model is employed to simulate an adsorption equilibrium on the flat walls of the honeycomb adsorbent. Appropriate surface boundary conditions for heat and mass transfer in the presence of adsorption/desorption are formulated. Model predictions are compared with available experimental data for adsorption of water vapor in a honeycomb column, and very good agreement is obtained between the numerical simulations of the system dynamics and the measurements. The findings demonstrate that it is important to correctly account for heat and mass transfer and adsorption/desorption interactions in the system.