The time history of mixing is known to play a crucial and non-trivial role in non-premixed turbulent combustion. In a first part, Eulerian balance equations are derived for both a flow residence time and a characteristic time of the mixing which the particles gathered in a fluid element have been subjected to in their flow histories. These equations are analyzed and solved in a Large Eddy Simulation (LES) context for a fuel jet mixing with an oxidizer co-flow. Typical responses of filtered mixture fraction versus flow residence time are highlighted. In a second part, a Flow-Controlled Chemistry Tabulation (FCCT) is devised in which the effects of unresolved fluctuations of thermochemical variables in LES are simulated, combining partially stirred reactors with tabulated chemistry. The reactor evolutions are organized to mimick flow engulfment and micro-mixing, so as to reproduce the observed filtered mixture fraction versus residence time response. This allows for dynamically building subgrid scale joint probability density functions, and thereby the subfilter response of the non-premixed flames, according to four control parameters: the filtered mixture fraction, the progress of reaction, the flow residence time, and a mixing time. Finally. LES of the Cabra et al. [Combust. Flame 143 (2005) 491-506] fuel-jet lifted-flame developing in a vitiated oxidizer environment is performed and results are compared against measurements. (C) 2011 The Combustion Institute. Published by Elsevier Inc. All rights reserved.