We present herein results from a campaign (>1500 h) of o-xylene oxidation runs in a 1 in. single-tube technical fixed-bed pilot reactor (i.d. = 24.6 mm) loaded with 16 washcoated (V2O5/TiO2) monolithic catalysts with Al honeycomb supports (each 10 cm long) and operated at typical industrial conditions for PA (phthalic anhydride) production. The highly conductive monolithic supports afforded substantially reduced axial T-gradients in comparison with reference runs in the same pilot reactor loaded with conventional egg-shell ring catalyst pellets, the maximum T-difference with the salt bath being halved at the same hot spot temperature (similar to 440 degrees C) and the mean bed temperature being about 20 degrees C higher. Temperature gradients were still moderate at an o-xylene feed concentration of 80 g/Nm(3) (at Q(air). = 4 N m(3)/h), which represents an upper limit for industrial PA packed-bed reactors loaded with the same V2O5/TiO2 catalyst coated onto ring pellets. Operation at higher o-xylene feed contents (up to 95 g/Nm(3)) was found feasible. The Al honeycomb catalysts were successfully unloaded at the end of the runs. The strong (similar to 2-fold) enhancement of radial heat transfer rates associated with the adoption of highly conductive monolith catalyst supports is thus herein demonstrated at a fully representative industrial scale for the first time. It can be exploited, for instance, either to increase the o-xylene feed concentration, possibly above 100 g/Nm(3) (and the PA productivity accordingly), within a retrofitting strategy, or to design new reactors with larger tube diameters, resulting in reduced investment costs.