The homochiral iron(III) wheels [Fe-6{(S)-pedea}(6)Cl-6] and [Fe-6{(R)-pedea)}(6)Cl-6] [(R)- and (S)-2; pedea = phenylethylaminodiethoxide] exhibit high optical activities and antiferromagnetic exchange. These homochiral products react with each other, producing the centrosymmetric, crystallographically characterized [Fe-6{(S)-pedea}(3){(R)-pedea}(3)Cl-6] diastereomer [(RSRSRS)-2]. H-1 NMR and UV-vis studies indicate that exchange processes are slow in both homo- and heterochiral systems but that, upon combination, the reaction between (R)- and (S)-2 occurs quickly.