Turbulent double-diffusive natural convection in a square cavity represents numerous important problems in practice as well as in fundamental. However up to date the study on it is quite sparse and most previous studies just focus on laminar regime. To the best knowledge of the present authors, only several k-epsilon models were developed to investigate turbulent double-diffusive convection and there is no attempt to use Large Eddy Simulation (LES). In order to deepen our knowledge on turbulent double-diffusive convection in a square cavity, we propose a novel LES-based lattice Boltzmann (LB) model to simulate such turbulent convectional flow. Previous LES-based LB models can be recovered from the present model. We find that the symmetry of the fluid circulation becomes broken since the Rayleigh number Ra = 10(8), although the asymmetry is more clear when Ra >= 10(10). More important, in the present study we find the power-law relationship among the Nusselt (Nu), the ratio of buoyancy forces (N) and the Rayleigh number (Ra) still exists in turbulent regime. The formula among them can be concluded as Nu = a x (Ra x vertical bar 1 - N vertical bar)(b) + c. The values of parameters a, b and c are given in this work. (C) 2012 Elsevier Ltd. All rights reserved.