The axial pressure drop for two-phase post-CHF dispersed flow along a rod bundle with a straight grid spacer was investigated experimentally. Thermodynamic non-equilibrium was considered in both the measurements and data analysis. The effects of Reynolds number and actual quality on the spacer pressure drop were also investigated. Experimental data on the frictional pressure drop in the unblocked section (e.g. without spacer) compared favorably with four well-known models. On the other hand, all available models substantially underpredicted the experimental pressure drop at the grid spacer. These deviations were attributed mainly to differences in flow patterns and heating conditions (diabatic vs adiabatic). Pressure drop values which are 300% higher than those predicted by Beattie’s model were suggested for post-CHF dispersed flow in straight grid spacers.