A rather new technique for the deposition of CIS layer has been discussed in this paper namely Electrospray Deposition (ESD). Thin films composed of Copper-Indium-diSelenide, have been achieved using the ESD technique for the ultimate manufacture of CIS based solar cell. CIS nano-particle inks are used in the ESD process for the deposition of similar to 2 mu m CIS layers on ITO coated substrates whereby ITO coating can be used as the back contact of the solar cell. Different parameters affecting the ESD process and the deposited layer thickness and uniformity such as stand- off distance, flow rate and voltage have been examined as well to come up with an optimized parameter combination. Layers with fine uniformity are achieved at two different substrate speeds, 0.5mm/s and 1.0 mm/s. The thickness of the deposited films varied from 400nm to 2.7 mu m with varying flow rate from 30 mu l/h to 230 mu l/h and 2.8 mu m-1.3 mu m with varying stand-off distance from 13 mm to 6 mm. The cost-effectiveness, room-temperature operation, environment friendliness and simplicity of ESD process with its possible integration with high throughput manufacturing processes like Roll-to-Roll process makes it an idyllic candidate for deployment in the solar cell fabrication process at a large scale. (C) 2010 Elsevier B. V. All rights reserved.