Market pressures are forcing biopharmaceutical manufacturers to maximize the efficiency of chromatographic operations to purify biotherapeutics more quickly and reliably. Along with trends: towards more frequent use of high throughput media, a number of innovations have been introduced to automate process chromatography over the past decade: Paul O'Neil[Euroflow Group] and Ian Sellick [Pall Corp] summarize recent innovations in process column.. packing, turning what was once a skilled craft into a science.