The relationships between microscopic properties such as interfacial shear strength (IFSS) and macroscopic properties such as flexural strength were investigated for CFRP prepared from carbon fiber and epoxy resin. Flexural, tensile and impact strengths all went through maximum values when plotted against the surface treatment time of the carbon fiber. The flexural strength of CFRP as a function of the treatment time of the carbon fiber behaved similarly to the adhesive strength of the resin and carbon fiber. Also, the results indicated that the behavior of tensile and impact strengths varied with the treatment time in much the same way as the interfacial shear strength did. The occurrence of these two types of macroscopic and microscopic property effects can be understood by taking into account the chemical activity and roughness of the carbon fiber surface.