Results from various enhancement techniques to improve the performance of a recently developed two-phase heat spreader are reported. The spreader has a central evaporator section, with an integrated condenser along the edges. A micro-fabricated three-dimensional enhancement structure is employed to improve the heat transfer performance of the spreader. This study considers the performance of several liquid coolants to be used with the device and evaluates the effect of initial pressures on the thermal performance of the spreader plate. Liquids with lower boiling points were found to result in lower wall temperatures of the spreader plate due to earlier onset of boiling. Studies also showed an improvement in heat transfer performance with increase in stack height of the enhancement structures used in the evaporator section.