| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 |
29권 1호, p.323 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation and characterization of dexibuprofen using self micro emulsifying drug delivery systems (SMEDDS) in vivo |
| 초록 |
Dexibuprofen as a model drug (ibuprofen isomer, non-steroidal anti-inflammatory) has very low solubility in water (0.03~2.5㎎/㎖). Because dexibuprofen is lipophilic material, it is easily solved in oil. Therefore, self-micro emulsifying drug delivery system (SMEDDS) was applied to improve drug solubility and bioavailability in vivo. In this study, tetraglycol as cosurfactant, Labrafil M1944cs as oil and Cremophor ELP as surfactant were mixed with dexibuprofen for formulation of SMEDDS. Also, amine as a pH adjuster was added to the pre-emulsion for improving its solubility. Droplet size of SMEDDS into water was determined 32㎚ size. In vivo experiment was performed in rat at the pre-determined set time. we extracted serum from the rat and quantitatively analyzed drug concentration by HPLC. From these results, we could achieve improved drug solubility and bioavailability using the SMEDDS. |
| 저자 |
안용산1, 강복기1, 김문석2, 조선행2, 이종문1, 이해방2, 강길선1
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| 소속 |
1전북대, 2한국화학(연) |
| 키워드 |
Dexibuprofen; SMEDDS; Amine; Vitamin E; In vivo
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| E-Mail |
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