| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Basic studies concerning TPP coated DES : Cytostatic effect of TPP on VSMCs, establishing coating condition |
| 초록 |
The drug-eluting stent implantation is a widely acceptable treatment for coronary heart disease. It was reported that iron chelator had anti-proliferative effect on human vascular smooth muscle cells (HA-VSMCs). In this study, tetraphenylporphine(TPP) was used to evaluate anti-proliferative effect on the cultivation of HA-VSMCs by MTT assay method. TPP and polycorprolactone(PCL) were coated onto stainless steel plate(ss-plate) using a spray-coating method. Surface morphologies of the TPP/PCL-coated plate were examined by AFM and SEM. HA-VSMCs proliferation was inhibited by the addition of TPP. TPP and PCL film coated by spray method was tightly adhered to the surface of ss-plate. TPP was released from ss-plate during two weeks. TPP as iron chelator can be used as drug for stent coating because of its anti-proliferative effect and sustain release profile. |
| 저자 |
박민희, 이우경, 심영기, 고원규, 남대식, Odonchimeg Munkhjargal, 김성철, 강수용, 박현정, 서진선
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| 소속 |
인제대 |
| 키워드 |
drug-eluting stent; porphyrin derivatives; tetraphenylporphine (TPP); polycorprolactone (PCL); iron chelation
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| E-Mail |
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