| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Anti-tumoral Activity of Doxorubicin-loaded In Situ-Forming Gel |
| 초록 |
We examined injectable in situ-forming gels as a localized drug delivery system of anticancer drug. An MPEG-PCL (MP) solution containing doxorubicin (Dox) existed in an emulsion-sol state at room temperature and gelled in vitro and in vivo at body temperature. The release of Dox from Dox-loaded MP gels was sustained in vitro over 20 days after an initial burst, indicating that the MP gel acted as a drug depot. Dox-loaded MP gels exhibited remarkable in vitro anti-proliferative activities against cancer cells. In vivo experiments employing cancer cell xenograft-bearing mice showed that a single intratumoral injection of Dox-loaded MP gel inhibited the growth of tumors as effectively as repeated injections of free Dox, or saline or gel alone. And most amount of Dox was found in tumor tissue following intratumoral injection, implying fewer off-target side effects. Overall, the locally delivered Dox-loaded MP gels described here would be ideal for future use against localized solid tumors. |
| 저자 |
강휘주, 김경해, 강꽃님, 김다연, 김재일, 김재호, 김문석
|
| 소속 |
아주대 |
| 키워드 |
intratumoral injection; doxorubicin
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| E-Mail |
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