| 초록 |
To improve the bioavailability of drugs, considerable effort has been devoted to the achievement of long-term in vivo release. A sustained drug delivery system using microsphere can offer practical possibility. In this study, we prepared NSAIDs-loaded microspheres using methoxy-poly(ethylene glycol)-poly(ε-caprolactone-co-L-lactide) (MPEG-PCLA). MPEG-PCLA were synthesized by ring-opening polymerization of ε-caprolactone and L-lactide with various compositions and molecular weights. Depending on the experimental conditions, we obtained a drug-loaded microsphere with encapsulation efficiency of 60-80% and a particle size of 40-100 μm. The drug-loaded microspheres exhibited cumulative release profiles of drug over 7 days. To evaluate the biocompatibility microspheres were subcutaneously injected into rats. It provoked only a modest inflammatory response in histological analysis. In conclusion, we confirmed that MPEG-PCLA microsphere can be used as a drug carrier for NSAIDs. |
