| 초록 |
p-HPGM(hydroxy-phenylglycine methyl ester) is an important intermediate production of amoxicillin. Amoxicillin had been prepared by biosynthesis method and recently it is synthesized with strong acid. With increasing demand of environmental regulations a use of strong acid often involves a control of hazardous substances throughout production, treatment of waste streams and emissions. Fisher-esterification which uses for production of p-HPGM is favored with a large excess of alcohol in the presence of a strong acid such as sulfuric acid and tosylic acid. Zeolites can help reduce a use of strong acid. Reaction of Fisher esterification is carried out over different ratios of Al/Si of HZSM-5 and HZSM-11 and compared. Synthesized zeolites were characterized with XRD, BET, EDX, FT-IR, Pyridine-TPD, UV-Vis. |
