| 초록 |
Nanoparticles made of biodegradable polymers have drawn a great deal of interest as drug delivery carriers. Polyethylene glycol (PEG) has been used to allow for various functionalities to such drug-delivery nanoparticles. In this work, therefore, we sought to obtain the optimized conditions for fabrication of drug-loaded nanoparticles composed of poly(lactic-co-glycolic acid) (PLGA) and PEG (MW = 6000). We employed dexamethasone sodium phosphate as a model drug with a relatively high water solubility. The nanoparticles were prepared via W/O/W double emulsion. To find the optimized conditions with a proper drug loading amount and sustained release property, we varied the durations for sonication, initial feeding amounts of drug and PEG, and volume of aqueous continuous phase. The loading amounts of drug and PEG were 12.5 and 29.4 μg/mg with the durations for sonication as 1 and 5 min, initial feeding amounts of drug and PEG as 300 and 200 mg, and volume of aqueous phase as 50 mL. |
