| 초록 |
In recent years, application of fluorescent conjugated polymers to sense chemical and biological analytes has received much attention for many researcher. Water-soluble conjugated polymers are being increasingly studied for biosensor because of their detection applications, such as DNA, proteins, and biological agents. We have attempted to synthesize water-soluble poly(para-phenylene) derivatives, such as poly[2,5-bis(3-sulfonatobutoxy)-1,4-phenylene-alt-1,4-phenylene] sodium salt and poly[2,5-bis(6-N,N,N-triethylammonium-1-oxapropyl)-1,4- phenylene-alt-1,4-phenylene] dibromide. We developed a method to introduce a benzaldehyde and 4-(bromophenyl)-maleimide group, a versatile functional group for bioconjugation, at both ends of PPPs chain. The synthesized polymers showed good solubility in water. The polymers containing benzaldehyde or 4-(bromophenyl)-maleimide end-group had binding capacity for biological analytes. |
