| 초록 |
Nano particle of Monoolein cubic phase has thermodynamically stable lipid bilayer by MO-water system. Cubic phase appeared honeycomb structure it can be include water solubility, lipoid solubility, poorly watersoluble Drugs. Cubic phase self-assembled and its not toxic even if it accumulated in the body due to natural, biocompatibility, biodegradable features in addition it is easy to release control. In this study, to assess stability according to storage temperature -25℃, 4℃, 25℃, 40℃ cubic phase and Artemisia Extract(Newaple) in cubic phase in dark condition incubator. Then evaluated the change in formulation of physical, chemical properties. In addition, the effect on stability was confirmed through viscosity, pH and formulation shift compare with cubic phase and Newaple in cubic phase. To check the persistence of the Newaple in cubic phase observing peak at 222nm wavelength by UV-Visible spectrometer. |
