| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Mannan-coated superparamagnetic iron oxide nanoparticles as magnetic resonance contrast agentfor lymph node imaging |
| 초록 |
To design the functionalized superparamagnetic iron oxide nanoparticles (SPIONs) demonstrating the capacities to be taken up by the macrophage cells within the lymph node specifically for the diagnosis of lymph node metastases. Mannan-coated SPIONs (mannan-SPIONs) were prepared by traditional coprecipitation method, followed by a thermochemical treatment and post-coating with mannan. The nanoparticles characterized by TEM, ELS, XRD and FT-IR. The cellular uptake of the mannan-SPIONs was assessed by FACS and their macrophage-targeted delivery was also investigated through in vivo lymph node MR imaging. Mannan-SPIONs exhibited enhanced targeted delivery efficiency to macrophages than PVA-SPIONs as a control. Therefore, mannan as a coating material not only prevented the aggregation of SPIONs in physiological medium but also provided a capacity to be delivered in macrophage specifically, suggesting of the potential utility of them as a contrast agent for lymph node imaging. |
| 저자 |
유미경1, Ji-Shan Quan1, 권진숙2, 정환정3, 정용연2, 박인규2, 조종수1
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| 소속 |
1서울대, 2전남대, 3전북대 |
| 키워드 |
Iron oxide nanoparticles; Mannan; Macrophage-targeting; Magnetic resonance imaging (MRI) contrast agent; Lymph node
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| E-Mail |
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