| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 | 28권 1호, p.173 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | In vitro release of piroxicam patch prepared by self-microemulsifying drug delivery system |
| 초록 | Piroxicam, non-steroidal anti-inflammatory with long half-life, is slightly soluble in alcohols and in aqueous alkaline solution and an optimal vehicle system for high skin permeation has been developed recently. In this study, a monolayer transdermal delivery system was designed and characterized to achieve adequate flux across the skin with the minimized lag time using the self-microemulsifying drug delivery system (SMEDDS). For this purpose, SMEDDS containing piroxicam with various oils and surfactants was formulated and the permeation studies were performed using Keshary-Chien diffusion cells. The skin was extracted from the abdomen guinea pig skin and hairless mouse and the permeated amount of proxicam was assayed by HPLC. The optimizing formulation for piroxicam patch was established by the consideration of main factors such as enhancers, drug concentration and adhesive and this preliminary result suggests a possible application of the SMEDDS as a transdermal delivery system of piroxicam. Acknowledgement : This work was supported by KMOCIE |
| 저자 | 길희주;강복기;서광수;정상영;육순홍;강길선;조선행;이해방 |
| 소속 | 한남대 |
| 키워드 | Piroxicam; self-microemulsifying drug delivery system (SMEDDS); transdermal delivery system |
