| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
대학원생 구두발표(영어발표, 발표15분) |
| 제목 |
Autofluorescence Turn on Technology: Tumor Guidance through Local Delivery System |
| 초록 |
Fluorescence-based imaging guidance for tumor resection has recently emerged as a fascinating tool using use of exogenous fluorescent contrast agents with objective and precise information of tumor tissues. For selective active tumor targeting, these contrast agents were chemically conjugated with targeting moieties such as antibodies and peptides, which often fail in Food and Drug Administration (FDA) approval due to safety issues. Motivated this point, we have developed nanocarriers to escape the most issues in regard to the clinical safety. In this study, we have demonstrated selective targeted “turn-on” fluorescence on delivery of nanocarriers to achieve excellent sensitivity with high signal-to-noise ratio. Owing to the non-toxic and distinct fluorescence, we expect that our nanocarriers developed in this study will be ‘extremely fast’ exploited for clinical use of fluorescent guided surgery. |
| 저자 |
정 윤1, 김가람1, 이병철1, 김상은1, 고원건2, 이강원1
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| 소속 |
1서울대, 2연세대 |
| 키워드 |
Tumor gudiance; Nanocarrier; Polymer Nanoparticle
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| E-Mail |
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