| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Effective implantation of outgrowth endothelial cells by extracellular matrix immobilization for promoting re-endothelialization of coronary stent |
| 초록 |
Reconstruction of collapsed endothelium is prominent for the prevention of in-stent restenosis and late thrombosis. To incorporate the blood vessel and promote angiogenesis, we modified the cobalt chromium (CoCr) stent with polydopamine (pDA) and fibronectin (FN), and constructed cell-derived extracellular matrix (ECM) via our decellularization method. To In vitro cell study, ourgrowth endothelial cells (OECs) were cultured on the ECM immobilized CoCr surfaces. The result showed that the ECM was successfully immobilized on the pDA/FN coated surface, and OECs are well attached on the ECM-immobilized CoCr surfaces compared to bare CoCr. In in vivo study, OEC implantation using ECM stent achieved higher re-endothelialization rates and lower neointima formation rates than BMS. These suggest that the OEC implantation using ECM stent would be an effective therapeutic treatment for accelerating re-endothelialization and suppressing complications. |
| 저자 |
김윤아1, 정미진1, 박광숙1, 김익환2, 김한별3, 김경석3, 홍영준3, 배인호3, 한동근4, 정윤기1
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| 소속 |
1한국과학기술(연), 2고려대, 3전북대병원, 4차의과학대 |
| 키워드 |
ECM immobilization; coronary stent
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| E-Mail |
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