| 학회 | 한국화학공학회 |
| 학술대회 | 2009년 가을 (10/22 ~ 10/23, 일산 KINTEX) |
| 권호 | 15권 2호, p.2136 |
| 발표분야 | 재료 |
| 제목 | Preparation of Heparin-Eluting Stent with TiO2 Coated by using PECVD |
| 초록 | Drug eluting stent was made of drug loading on polymer coated metal stent. But polymer coated stent has show some troubles when drugs were consumed. In this work, TiO2 thin film was coated onto metal stent surface instead of organic polymer because TiO2 was known as biocompatable material. TiO2 thin film was deposited onto metal stent surface by PECVD process using TTIP (Titanium(Ⅳ) isopropoxide) as a precusor and oxygen gas as reactive gas at 400℃. Then deposited TiO2 surface was modified by low temperature plasma process to enhance functional groups. for drug grafting. Optimal modification conditions were investigated by changing RF discharge power and treatment time. Then, carboxylic groups in heparin was grafted onto modified TiO2 surface by esterification reaction at 60℃, 1hr in acidic condition. Surface morphology, chemical structure and atomic composition of TiO2 deposited and heparin grafted surface were analyzed by FE-SEM, FT-IR/ATR, ESCA, respectively. Quantitative analysis of grafted heparin onto a stent was measured by UV-visable spectrometer at 631nm. In-vitro drug eluting test was performed in PBS buffer. |
| 저자 | 박유정1, 조동련1, 김경석1, 송선정2, 조명덕1 |
| 소속 | 1전남대, 2기능성나노소재사업단 BK21 |
| 키워드 | Drug eluting stent; TiO2; heparin |
| 원문파일 | 초록 보기 |
