| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Self-crosslinking injectable hydrogels containing protein-releasing gelatin microspheres |
| 초록 |
Novel hydrogel matrices are being sought for a number of biomedical applications, including drug and protein delivery. In this work, a self-crosslinking injectable poly(amino acid)-based hydrogel with encapsulated protein-releasing gelatin microspheres was developed for an efficient protein delivery system. The self-crosslinking hydrogel can act as an injectable depot at lesion sites, and incorportated gelatin microspheres, prepared by precision particle fabrication technology, can provide the precise control over protein release. Thus, the combination of these two species may provide a useful injectable formulation for a diverse class of therapeutic proteins, by expressing many benefits, such as accurately controlled protein release, comport to the patients, and cost reduction of surgery due to the non-invasive administration. Acknowledgement. This study was supported by a grant (code #:10024816) from R&D Program for “International Joint Technology Development Project” by MOCIE. |
| 저자 |
이홍재1, 김찬우1, 김성은1, 김경자1, 최형수2, 김계균2, 이상천1
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| 소속 |
1요업(세라믹)기술원, 2Univ. of Illinois |
| 키워드 |
self-crosslinking; injectable hydrogel; gelatin microsphere; protein delivery
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| E-Mail |
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