| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
In vitro and in vivo characteristics of porous chitosan scaffolds with surface-immobilized nano-hydroxyaptite |
| 초록 |
The surface engineering of scaffold pores is one of the most important subjects to develop high-performance bone-regenerative materials, since it determines whether cells can effectively adhere, migrate, and proliferate on porous scaffolds. Recently, we developed a new fabrication approach for hybrid scaffolds by immobilizing nano-HAp on the pore surfaces of chitosan scaffolds. In this work, we describe in vitro and in vivo characteristics of these hybrid scaffolds by estimating osteogenetic properties and bone regeneration. The biological characteristics of hybrid scaffolds strongly supported that scaffolds with surface-immobilized nano-HAp provided more favorable environments for cell-scaffold interaction, osteogenesis, and in vivo bone formation. Acknowledgement. This research was supported by a grant (code #: 07K1501-01510) from 'Center for Nanostructured Materials Technology' under '21st Century Frontier R&D Programs' of the Ministry of Science and Technology, Korea. |
| 저자 |
김성은, 최형우, 이홍재, 김찬우, 김경자, 이상천
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| 소속 |
요업(세라믹)기술원 |
| 키워드 |
porous chitosan scaffolds; surface-modification; bone regeneration; tissue engineering
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| E-Mail |
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