| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation and Evaluation of Self nano-emulsified Paclitaxel System. |
| 초록 |
The aim of this study was to examine various formulations of PTx-loaded SMES to increase systemic clearance through extending of the circulation time of PTx. The prepared PTx-loaded SMES showed the size of the range of 80130 nm by dynamic light scattering and a spherical shape by atomic force microscopy. The stability of PTx-loaded SMES depended on the molecular weights of PLGA and concentration of PTx. The PTx-loaded SMES exerted a significant inhibitory effect on cell proliferation. The cell viability was approximately 40% and 20% at 4 days and 7 days, respectively. We found the formulation of the PTx-loaded SMES with stability for 7 days. The formulation in this work could be used as administration form for animal trials. Thus, further research on the animal model using PTx-loaded SMES prepared in this work is now in progress. |
| 저자 |
김이슬1, 강윤미1, 김경해1, 강꽃님2, 김다연2, 박고운1, 이빛나1, 이봉2, 김재호1, 윤영필3, 김문석1
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| 소속 |
1아주대, 2부경대, 3대전선병원 |
| 키워드 |
SMEDDS; Paclitaxel
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| E-Mail |
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