| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Regeneration of Bone Tissue using Silk Fibroin-PGA Hybrid Scaffolds Prepared by Electrospinning and 3D Printing Techniques |
| 초록 |
Tissue engineering aims regeneration of defected biological tissues and organs by combining cells, scaffolds, and growth factors. We developed patient-customizable guided bone regeneration (GBR)/guided tissue regeneration (GTR) hybrid scaffolds prepared by electrospinning and 3D printing techniques. Poly(glycolic acid) (PGA) scaffolds were prepared by a 3D printer. The topography of silk fibroin nanofibers and PGA scaffolds was observed by SEM. Cell seeding efficiency and proliferation of osteoblasts on a PGA scaffold were analyzed by MTT assay. Rabbit calvarial defect model was used for animal test. Bone tissue regeneration were analyzed by Masson Trichrome staining and micro-CT. Silk fibroin nanofiber-PGA hybrid scaffold groups showed significant regeneration of bone compared to control groups. The silk fibroin nanofiber-PGA scaffold construct will be an efficient approach for regeneration of bone defects. |
| 저자 |
곽동민, 고영광, 이경우, 김귀재, 권오형
|
| 소속 |
금오공과대 |
| 키워드 |
3D Printing; Electrospinning; Barrier membrane; Implant; Guided bone regeneration; Guided tissue regeneration
|
| E-Mail |
|
