학회 |
한국고분자학회 |
학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
권호 |
33권 1호 |
발표분야 |
의료용 고분자 |
제목 |
Effect of DBP Content on Proliferation and Phenotype of Olfactory Ensheathing Cell on DBP/PLGA Scaffold |
초록 |
Olfactory ensheathing cells (OEC) have been reported to migrate long distances after spinal cord injury (SCI). Bone morphogenetic proteins (BMPs)have numerous functions in nervous system development. In this study, we investigated interaction of OEC with PLGA/DBP scaffold according to content of DBP. We manufactured PLGA/DBP scaffold by solvent casting/salt leaching method. Cell proliferation seeded into the scaffold were assayed MTT test and NF, S-100, P75, BDNF were expressed in OEC cultured PLGA/DBP scaffold according to content of DBP. We examined the cell adhesion and proliferation by SEM observation. We confirmed that OEC adhesion and proliferation was increased on PLGA/DBP scaffold of higher content of DBP. In these results, we recognized that PLGA/DBP scaffold provide the suitable environment for improvement of cell proliferation and formation of extra cellular matrix. This research was supported by KMOHW (0405-BO01-0204-0006) and SCRC (SC3100). |
저자 |
김근아1, 김수미1, 김순희1, 김초민1, 오아영1, 이일우2, 이종문1, 강길선1, 이해방3
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소속 |
1전북대, 2가톨릭대, 3한국화학(연) |
키워드 |
Olfactory Ensheathing Cell |
E-Mail |
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