| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
대학원생 구두발표 (발표15분) |
| 제목 |
On-site Fabrication of Injectable Biodegradable 131I-Labeled Microgels for Local Radiotherapy |
| 초록 |
Nuclear medicine is an important clinical options for diagnostic imaging and disease treatment. Encapsulating radioisotopes in injectable hydrogels is ideal for achieving long-term, low-dose radiotherapy by targeting radionuclides to tissues or organs. However, difficulties in the on-site fabrication of radioactive hydrogels during treatment and unpredictable radiation levels at the target site are major obstacles to clinical use. Here, we developed a strategy that facilitates the on-site fabrication of radioactive microgels requested in clinical environment using a 131I-labeled hyaluronic acid (HA) and a microfluidic system. This approach allows for on-site fabrication of injectable, radioactive, biodegradable (IRB) HA microgels, enabling immediate therapeutic application with improved local retention. We demonstrated the clinical utility of this comprehensive approach by preparing IRB HA microgels within 15 min and localizing them beyond 1 week to minimal off-target biodistribution. |
| 저자 |
김소담1, 임상구1, Ajeesh Chandrasekharan1, 성금용1, 이태욱1, 이유진2, 김근영1, 최성용2, 양승윤1
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| 소속 |
1부산대, 2한양대 |
| 키워드 |
Injectable drug delivery system; radiotherapy; hyaluronic acid; 131I; hydrogel microparticle
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| E-Mail |
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