| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Release of anti-restenosis drugs from polyethylene glycol-co-poly(DL-lactic-co-glycolic acid) nanoparticles. |
| 초록 |
Coronary arterial stenting with drug-eluting stent (DES) is a major therapy for the treatment of coronary arterial diseases inpresent interventional cardiology practice. Rapamycin has anti-inflammatory activity. So, the rapamycin-eluting stents were extensively studied by many people and many meaningful results were obtained. Rapamycin-loaded nanoparticles based on polyethylene glycol (PEG) and poly(DL-lactic-co-glycolic acid)(PLGA) block copolymers (PEG-PLGA) were prepared by dialysis method. The morphology of Rapamycin loaded nanopaticles observed by transmission electron microscopy had spherical shapes with particle size of ＜50nm. Anti-restenosis drug loaded nanoparticles showed high drug loading efficiency over 75 % (w/w). Rapamycin was continuously released from nanopaticle over 3 week. |
| 저자 |
김동곤1, 박준규1, 남정표1, 최창용1, 정영일2, 장미경1, 나재운1
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| 소속 |
1순천대, 2양산부산대 |
| 키워드 |
Anti-restenosis drug; Rapamycin; PEG-PLGA; nanopaticle; stent
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| E-Mail |
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