| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 | 29권 1호, p.180 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Physicochemical Properties of Thermosensitive Nanoparticles by Self-assembly of Poly(N-isopropylacrylamide)-Poly(ε-caprolactone) and Poly(ethylene glycol)-Poly(ε-caprolactone) Block Copolymers |
| 초록 | Polymeric amphiphiles, containing hydrophilic and hydrophobic components, have been extensively studied in biotechnology and pharmaceutical fields due to their unique properties of micelle or micelle-like self-aggregate formation in aqueous milieu. In this study, the well-defined PNIPAAm-PCL and PEG-PCL block copolymers were synthesized by ring-opening polymerization of ε-caprolactone using mPEG-OH and PNIPAAm-OH, prepared by telomerization of NIPAAm, as initiators. Thermosensitive nanaparticles, with various PNIPAAm-PCL/PEG-PCL ratios, were prepared by a diafiltration method. Then, the physicochemical properties, such as thermosensitivities, self-aggregation behaviors and microscopic characteristics of the thermosinsitive, were investigated by 1H NMR, DSC, DLS and fluorescence spectroscopy. |
| 저자 | 최창용, 김태형, 채수영, 김명열, 나재운 |
| 소속 | 순천대 |
| 키워드 | Thermosensitive Nanoparticle; Poly(N-isopropylacrylamide); Poly(ethylene glycol)-Poly(ε-caprolactone) |
