| 학회 |
한국공업화학회 |
| 학술대회 |
2004년 가을 (10/29 ~ 10/30, 호서대학교(아산캠퍼스)) |
| 권호 |
8권 2호 |
| 발표분야 |
나노 |
| 제목 |
The performance of poly(DL-lactide-co-glicolide) nanoparticles without surfactant as potential carriers for drug delivery |
| 초록 |
The performance of poly(DL-lactide-co-glicolide) (PLGA) nanoparticles without surfactant or emulsifiers was investigated by a dialysis method. The size of the PLGA nanoparticles prepared from dimethylacetamide (DMAc) as an initial solvent was smaller than that from acetone. The sizes of the PLGA nanoparticles from DMAc and acetone were 200.4 ± 133.0 and 642.3 ± 131.1 nm, respectively. The effects of the initial solvent selected to dissolve the copolymer and the lactide:glycolide ratio were investigated. The PLGA nanoparticles were spherical as revealed by the results of scanning electron microscopy and transmission electron microscopy observations. From these results it was shown that PLGA nanoparticles could be formed by the dialysis method without surfactant. The drug-loading contents and efficiency were also dependent on the lactide:glycolide ratio and initial feeding amount of the drug. A higher lactide ratio resulted in higher drug loading and higher loading efficiency. However, a higher initial feeding amount of the drug resulted in higher drug loading and lower loading efficiency. |
| 저자 |
Vu-Giang Nguyen, 장미경, 김명열, 나재운
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| 소속 |
순천대 |
| 키워드 |
PLGA; Nanoparticle; without surfactant; norfloxacin; dialysis
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| E-Mail |
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