| 초록 |
Biodegradable poly(lactide-co-glycolide) (PLGA) have found widespread use in modern medical practice. However, it`s degradation rate is relatively slow for soft tissue regeneration especially to restore of skin and mucosa. The purpose of this study is to examine the effect of E-beam irradiation on degradation behavior of PLGA nanofibers. PLGA nanofibrous mats were prepared by electrospinning, and were E-beam irradiated at radiation doses of 50, 100, 150, 200, 250 and 300 kGy. The degradation of the PLGA nanofiber was studied by measuring the changes in weight, FTIR spectra, thermal and morphological properties. The results showed that an increase of hydroxyl (OH) group peak intensity with increasing radiation dose during degradation experiments indicates that hydrolytic degradation is acceleration by E-beam radiation. From this result, it is concluded that biodegradation behavior of PLGA nanofibrous scaffolds can be modulated by E-beam irradiation with varying irradiation dose. |
