| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Reactive oxygen species-responsive nanophotosensitizers for photodynamic treatment of oral carcinoma cells |
| 초록 | PDT has been extensively investigated for cancer treatment becausephotosensitizers generate ROS. Traditionalphotosensitizers are freely dispersed in the whole body because they have no specificityagainst tumor. Then, we synthesized phenyl boronic acid pinacol ester(PBAP)-conjugated chitosan using thioketal group (ChitoPBAP) for ROS-sensitivedelivery of Ce6. Ce6-incorporated nanophotosensitizers (Ce6-ChitoPBAP NP) were evaluated with AT84 oral cancercells. Ce6-ChitoPBAP NP has spherical morphology and showed ROS-sensitiverelease behavior of Ce6. Ce6-ChitoPBAP NP resulted in increased Ce6 uptakeratio, ROS production and phototoxicity against AT84 cells. At in vivoanimal tumor imaging study, Ce6-ChitoPBAP NP efficiently targeted solid tumorof AT84-bearing mice. Acknowledgement:This study was supported by the National Research Foundation of Korea (NRF)grant funded by the Korea government (MSIT) (No. 2020R1A2C1102850). |
| 저자 | 김창영, 김병훈, 정영일 |
| 소속 | 조선대 |
| 키워드 | 광역동 치료; 구강암세포; 나노광역동 치료제; 표적치료 |
