| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
[생물공학] 바이오팩토리 합성 최신현황과 차세대응용 |
| 제목 |
Engineering therapeutic anti-SARS-CoV2 antibodies for enhanced efficacy, reduced adverse effects, and prolonged serum half-lives |
| 초록 |
Antibody therapeutics with extraordinary high target specificity and low side effects compared to small-molecular chemical drugs can provide an effective means for the treatment of new emerging infectious diseases such as COVID-19. In this presentation, I will briefly introduce various antibody discovery methods and directed evolution strategies to improve the functions of antibodies. And then, I will present our two recent works, i) isolation of human antibodies against SARS-CoV-2 using human naïve immune antibody library and ii) molecular evolution of SARS-CoV specific antibodies to SARS-CoV2 specific antibodies. In addition, a variety of techniques to modulate effector functions and circulating half-lives of anti-viral therapeutic antibodies that have been recently developed in our laboratory will be discussed. |
| 저자 |
정상택, 이지선, 정인지, 김보미
|
| 소속 |
고려대 |
| 키워드 |
SARS-CoV-2; Therapeutic Antibody; Antibody Engineering
|
| E-Mail |
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