| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Application of Chitosan/PLGA Bilayered Nanofibrous Mat to Anti-adhesion Barrier |
| 초록 |
Post-operative peritoneal adhesions are common and give serious complications for surgeons. They can cause pelvic pain, infertility, and potentially lethal bowel obstruction. This study was designed to evaluate the effect of bilayered nanofibrous mat containing non-steroidal anti-inflammatory drug on the prevention of post-surgical tissue adhesion. For this, bilayered nanofibrous mats composed of chitosan and PLGA were fabricated by electrospinning method. The bilayered Chitosan/PLGA nanofibrous mat was characterized by several spectroscopic methods. Results from cytotoxicity and tensile test showed that bilayered Chitosan/PLGA nanofibrous mat was suitable for anti-adhesion barrier. From in vivo animal test, it was observed that bilayered nanofibrous sheets were significantly effective in preventing post-operative adhesion and wound healing. |
| 저자 |
이재백1, 김선종1, 김원일2, 권오경3, 권오형1
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| 소속 |
1금오공과대, 2원바이오젠, 3칠곡경북대 |
| 키워드 |
Chitosan; PLGA; Electrospinning; Nanofiber; bilayer; Peritoneal adhesion
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| E-Mail |
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