| 초록 |
Chitosan as a biocompatible natural polysaccharide has been investigated as versatile polymeric scaffolds for the systemic delivery platforms and locally injectable gels. However, many of such chitosan derivatives often suffer from the low aqueous solubility over a wide range of pH conditions and extremely high viscosity, which significantly limits their broad applicability. Herein, the native chitosan has been ligated with poly(ethylene glycol) for the enhanced solubility at neutral pHs, followed by the chemical modification with malonic acid that can be utilized as a bidentate ligand for cisplatin pharmacophore (PtII), a well-known anticancer agent. The resulting PtII-coordinated, PEGylated chitosan has been self-aggregated into nanoscale structures. Their characterization and colloidal properties will be discussed. |
