| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Chondrogenic differentiation of human adipose tissue-derived stem cells using dual growth factors loaded nanocarrier-fibrin-PLCL complexes |
| 초록 |
We induced chondrogenic differentiation of human adipose tissue derived stem cells in situ by effective stimulation via the continuous controlled release of dual growth factors from a pluronic-based nanocarrier-fibrin-PLCL complex. The hASCs suspended in a solution of fibrin gels and growth factor loaded functional nano-carriers were seeded onto PLCL scaffolds. They were implanted into the subcutaneous dorsum of athymic mice to investigate in situ chondrogenic differentiation. Dual growth factors loaded pluronic based nano-carriers for effective chemical stimulation with continuous controlled release and the hybridization of fibrin gels and a PLCL scaffold for 3-D spatial organization of cells would encourage hASCs to differentiate to chondrocytes and to maintain their phenotypes. Consequently, this system could facilitate cartilaginous tissue formation and enhance the quality of cartilaginous tissue formed. |
| 저자 |
김지은1, 정영미1, 김수희1, 최원일2, 태기융2, 김영하2, 김찬화3, 김상헌1, 김수현1
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| 소속 |
1한국과학기술(연), 2광주과학기술원, 3고려대 |
| 키워드 |
Chondrogenic; PLCL; BMP-7; TGFβ-1; nanocarrier; adipose stem cell
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| E-Mail |
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