| 초록 |
There are some failures in stent implantation, such as the in-stent restenosis (ISR) and late stent thrombosis (LAST). Although drug-eluting stents (DES) are quite successful to reduce the incidence of ISR, it suffers from poor re-endothelialization. In this study, we focus on the introduction of growth factor onto the surface of stent for rapid re-endothelialization. In the first step, the oxidized stainless steels were covalently coated with functional silane compound. These functionalized surfaces were further coupled with heparin. Heparin binds with growth factor and provides a sustained release system. In addition, to avoid a possible problem caused by anticoagulant activity of heparin, we used over-sulfated heparin showing reduced anticoagulant activity. We applied the vascular endothelial growth factor (VEGF) for re-endothelialization, and checked the cell behavior depending on VEGF release with Human umbilical vein endothelial cells (HUVECs). |
