| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Mesenchymal stem cells differentiation in porous alginate hydrogels constructed with magnesium oxide as porogen |
| 초록 |
Alginate hydrogels have many advantages as biomaterials for tissue engineering. However, one of the drawbacks of alginate hydrogels is the absence of micron-sized pores that support the proliferation and the differentiation of stem cells in three dimensional environments. It is known that stem cell fate can be guided by physical and biochemical signals of microenvironments. Herein, we utilized magnesium oxide as porogen to overcome the drawback of alginate hydrogels and investigated the effect of magnesium ions to mesenchymal stem cells (MSCs) as biochemical signals. We studied both mechanical and chemical signals to induce differentiation of MSCs in 3D culture environments. Alginate hydrogel-systems developed in this study can be potentially used in cell based therapeutic application as well as cell-mechanotransduction study. |
| 저자 |
김우준1, 박지민2, 이선희1, 송보아3, 윤다영1, 전호정1, 김유찬1, 이강원1
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| 소속 |
1한국과학기술(연), 2한국과학기술연구워, 3한국과학기술연구운 |
| 키워드 |
porous alginate; mechanotransduction; mesenchymal stem cell; differentiation; Magnesium
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| E-Mail |
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