| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Comparison of Cellular Uptake and In Vivo Tumor Accumulation of Surface Functionalized and Bare PLGA Nanoparticles in Tumor-Bearing Mice |
| 초록 |
The PLGA nanoparticles, coated by the chitosan or heparin-Pluronic conjugate, were prepared to overcome an intrinsic limitation of relatively low tumor accumulation due to their hardness. The functionalized nanoparticles and bare control did not show aggregation by serum proteins, and cytotoxicity to both normal and tumor cells. However, the cell uptake and in vivo tumor accumulation of the functionalized nanoparticles were significantly enhanced over control. Thus, the benefits of surface functionalization were to facilitate nanoparticle accumulation in the tumor tissue, which could be strongly related with an improved intracellular uptake. ***This research was partially supported by Basic Science Research Program through NRF funded by MEST, Korea (R15-2008-006-02002-0), and by WCU program at GIST through a grant provided by MEST (R31-2008-000-10026-0). |
| 저자 |
정용일1, 김종철1, 김영하1, 태기융1, 이승영2, 김광명2, 권익찬2
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| 소속 |
1광주과학기술원, 2한국과학기술(연) |
| 키워드 |
Tumor accumulation; PLGA nanoparticle; Heparin; Chitosan
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| E-Mail |
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