| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Biomimetic nanofilament-integrated multicellular spheroids and their microstructure-assisted assembly for vascularized adipose tissue formation |
| 초록 |
The variety of mammalian cells have been employed for forming multicellular spheroids aiming at targeted differentiation and phenotypic stabilization, as well as the simulation of 3D physiological condition. Especially, the multicellular spheroid used as a building unit in engineered tissue construction afford the possibility for their promising application. Human mesenchymal stem cell (hMSC) is promising source for regenerative medicine due in large part to their self-renewal capacity and their multipotency. Herein, we provide novel hierarchical and multifunctional scaffold design concept via two-step process consisting of the preparation of biomimetic nanofilament-integrated multicellular hMSC spheroids and subsequent spheroids-based assembly aided with precisely controlled microstructure as a solid structural framework. The 3D construction is realized through interlocking each spheroids-microstructure hybrid by additive layer-by-layer manner. |
| 저자 |
김택경, 박태관
|
| 소속 |
한국과학기술원 |
| 키워드 |
mesenchymal stem cell; multicellular spheroid; tissue engineering scaffold; adipose tissue
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| E-Mail |
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