| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Self-assembled Micelle-type Cationic Nanoparticles Based on Polyethlenimine- Poly(lactic-co-glycolic acid) Conjugate for Gene Delivery |
| 초록 |
During last decades, a lot of synthetic gene carriers have been proposed for non-viral gene delivery. Among the synthetic polymers, polyethylenimine(PEI) is one of the most widely used non-viral gene carriers. In this study, an amphiphilic PEI-abased coploymer conjugate was synthesized. Poly(lactic-co-glycolic acid) (PLGA), an NIH-approved biodegradable polymer, was employed as a hydrophobic partner of the conjugate. The chemical structure of the conjugate was determined by using H-NMR analysis. The copolymer formed micelle-like aggregates with critical association concentration (cac) in 2.55×mg/ml. The cationic nano-aggregate could interact with plasmid DNA via ionic force, resulting in the formation of polyelectrolyte complexes with a size ca. 200 nm. The self-assembled nano-aggregate having a micelle-like core-shell structure could be used as a functional vehicle for simultaneous delivery of therapeutic genes and water insoluble drugs. |
| 저자 |
오태환1, 김현준1, 김택경2, 김혜성3, 유혁상3, 박태관2, 정지훈1
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| 소속 |
1성균관대, 2한국과학기술원, 3강원대 |
| 키워드 |
Self-assemble; cationic micelle; gene delivery
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| E-Mail |
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