| 학회 | 한국공업화학회 |
| 학술대회 | 2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 | 21권 2호 |
| 발표분야 | (정밀화학) 의학 진단 화학 프로브 및 약물 개발 |
| 제목 | Fluorescent Probes for Tumor Diagnosis |
| 초록 | In this presentation, we will discuss interesting fluorescent probes for tumor imaging with enzymatically activated fluorophores. The activatable fluorescent probes from hemi-cyanine was developed for selective and sensitive detection of tumor-enridched g−glutamyltranspeptidase (GGT).[1, 2] The probes exhibited a dramatic fluorescence enhancement (F/F0 = 10) or ratiometric florescence response upon the addition of GGT with a limit of detection of 0.15 mU/mL and were applied for the successful detection of colon cancer in the mouse model. References 1. S. Park, S.-Y. Lim, S. M. Bae, S.-Y. Kim, S.-J. Myung,* H.-J. Kim,* "Indocyanine-based activatable fluorescence turn-On probe for g-glutamyltranspeptidase", ACS Sens. 2016, 1, 579-583 2. S. Park, D. J. Bae, Y.-M. Ryu, S.-Y. Kim, S.-J. Myung,* H.-J. Kim,* "Mitochondria-targeting ratiometric fluorescent probe for g-glutamyltranspeptidase and its application to colon cancer", Chem. Commun. 2016, 52, 10400-402. |
| 저자 | 김해조 |
| 소속 | Hankuk Univ. of Foreign Studies |
| 키워드 | Colon; Fluorescence; Glutamyltranspeptidase |
