| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
(여성인재육성) 젠더혁신 전문가 특강 및 WISET·KSIEC 젊은연구자상 수상자 발표 |
| 제목 |
Novel 3D printed alginate–BFP1 hybrid scaffolds for enhanced bone regeneration |
| 초록 |
Novel alginate–peptide hybrid scaffolds for bone regeneration was prepared via facile click chemistry and 3D printing technology. Bone formation peptide-1 (BFP1), a fragment derived from bone morphogenetic protein-7 (BMP-7), was loaded into the scaffolds to promote bone regeneration. The alginate–BFP1 conjugates were synthesized by EDC/NHS coupling reaction and then cross-linked in the presence of calcium ions (Ca2+) to form hydrogel networks. The dose-dependent cytotoxicity of CaCl2 was evaluated to optimize the amount of Ca2+ for fabrication of scaffolds. In vitro and in vivo studies indicated that the alginate-BFP1 scaffolds provided a stable environment for the growth of human adipose-derived stem cells (hADSCs) and led to a synergistically enhanced bone regeneration. |
| 저자 |
고나래1, 허은영1, 배민수1, 이상진1, 최병준1, 김정호1, 김형근2, 박수아3, 권일근1
|
| 소속 |
1경희대, 2전남대, 3한국기계(연) |
| 키워드 |
Tissue engineering; Hydrogel scaffold; BFP1; 3D printing; Bone regeneration
|
| E-Mail |
|
