| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Size-controllable and scalable synthesis of highly monodisperse silica nanoparticles in alkaline buffer solution and their size-dependent distribution in sentinel lymph node |
| 초록 |
Here, a scalable synthesis of highly monodisperse small silica nanoparticles with wide size-range was achieved via fine tuning of reaction temperature in various alkaline buffer solutions as catalysts. We performed in vivo fluorescence imaging and immunofluorescence analysis of sentinel lymph nodes (SLNs) with the nanoparticles having different sizes to investigate the size-dependent effect for SLNs identification. The 12 nm-sized nanoparticles showed effective SLN uptake within 10 min after intradermal injection and were evenly localized inside the SLN, whereas the 120 nm-sized nanoparticles failed to identify the SLN and distributed only in the medulla region not in the superficial cortex of the SLN. Taken together, a new facile scalable synthesis technique for fine size controlling of silica nanoparticles was developed and it made possible to find the optimized size of nanoparticles for efficient SLN mapping. |
| 저자 |
김훈섭, 박원철
|
| 소속 |
서울대 |
| 키워드 |
silica nanoparticle; precise size control; lymph node imaging
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| E-Mail |
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