| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Preparation of Catechol-Anchored Polymer Crosslinked to Dopamine-Conjugated Pluronic for Temperature Sensitive and Adhesive Hydrogels |
| 초록 |
A thermo-responsive and injectable hydrogel were prepared between catechol-anchored polymers with dopamine-functionalized Pluronic for adhesive hydrogel purpose. The hydrogel was achieved by synthesizing the catechol-anchored polymer by quaternized 2-chloro-3′, 4′-dihydroxyacetophenone (CCDP) into poly(dimethyl aminoethyl methacrylate)-co-(t-butylmethacrylate) which then crosslinked with dopamine-functionalized Pluronic. The dopamine-functionalized Pluronic crosslinked CCDP-q-PDB appears as a viscous solution in room temperature which then changes state into gel when the temperature increased. At optimum ratio of dopamine-Pluronic with catechol-anchored polymer (14:8 wt %), gel suitable for use in the body was easily acquired. In the end, thermo-responsive hydrogels demonstrated astonishing properties which can be used for drug delivery application. This work was supported by Korea National University of Transportation in 2018. |
| 저자 |
노상규, 박성영
|
| 소속 |
한국교통대 |
| 키워드 |
injectable hydrogel; thermo-responsive hydrogel; adhesive hydrogel; catechol; Pluronic; drug delivery
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| E-Mail |
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